Ezra S. Griffin was born in 1835 in Providence, Pennsylvania and resided there until he enrolled in Company I, 143rd Pennsylvania Infantry on August 15, 1862 at Hyde Park, Pennsylvania.  He mustered into the Civil War on September 6, 1862 as a 1st Lieutenant at Camp Luzerne, Pennsylvania.  Lt. Griffin was promoted from 2nd Lieut., January 30, 1863.  Lt. Griffin’s leg was shattered at the siege of Petersburg, Virginia on June 18, 1864.  He died at the age of 29 on July 11, 1864 in Annapolis, Maryland as a result of this wound.  He is buried in the Dunmore Cemetery, Dunmore, Pennsylvania.

The 143rd Regiment Infantry was organized at Wilkes-Barre October 18, 1862. Lt. Griffin and the rest of the regiment left the state for Washington, D.C., November 7, and duty in the Defenses of that city until January 17, 1863. The unit was attached to 1st Brigade, Defenses of Washington, north of the Potomac, to January, 1863; 2nd Brigade, 3rd Division, 1st Army Corps, Army of the Potomac, to December, 1863; 1st Brigade, 3rd Division, 1st Army Corps, to March, 1864 and 3rd Brigade, 4th Division, 5th Army Corps, to June, 1864 until he was wounded in action.